Organoid Intelligence (OI) brings together human brain organoids, sensor technologies, machine learning, and computational analysis to model neural plasticity, learning, and memory in human-relevant experimental systems. This approach supports biomedical research by enabling investigation of complex processes underlying brain development and function, modeling of neurological disorders, and assessment of how drugs, toxicants, and environmental exposures affect the nervous system. From disease modeling to exploring the potential of biological computing, OI opens new frontiers for advanced in vitro models of human brain function and informs next generation of computing systems such as neuromorphic computers.
Recognizing the transformative potential of OI, the Johns Hopkins University Center for Alternatives to Animal Testing has established this website as a central hub for researchers, technologists, ethicists, and policymakers. Our mission is to foster an interdisciplinary collaboration that will spearhead the development and ethical deployment of OI technologies. Here, you will find a comprehensive collection of resources, research findings, ethical considerations, and a platform for dialogue aimed at navigating the challenges and maximizing the benefits of this exciting new field. As we stand on the cusp of a new era in science and technology, our commitment is to ensure that the development of OI is guided by strategic thinking, safety standards, and a shared vision for a future. Join us in exploring the vast potential of organoid intelligence and in shaping the path towards its responsible and innovative application.